EndoTrex is a theanine spray for children to help combat the affects of ADHD. The aging mind also needs theanine. Theanine has the potential to become a natural alternative to Ritalin for treating ADHD.


EndoTrex is an easy to administer root beer flavored oral spray containing theanine. Theanine is a free (non-protein) amino acid. It is a relaxant that increases alpha-waves producing mental and physical relaxation decreasing stress and anxiety, without inducing drowsiness. It is useful in combating hyperactivity from overstimulation and from rebounding from stimulant medication.

For "Fast Focus", we offer a purse size theanine spray that seems to come in handy for our child. She thinks the name should be changed to "Fast Focus" because that is what it provides.

For More info on EndoTrex go To NeuroScience Inc.
New 60ml Size	EndoTrex can quickly reduce the dumping/excretion of neurotransmitters and provide a calming / relaxing effect for ADD or ADHD patients. This formula is designed to address over-stimulation and is used in young patients with an increased GABA excretion as often seen in ADD / ADHD.       GABA is the primary inhibitory neurotransmitter in the brain and regulates neurotransmitter activity to prevent over stimulation/hyperactivity. EndoTrex contains the amino acid theanine, which has been widely studied for its ability to provide a calming effect and prevent over stimulation. Several studies match observations by NeuroScience that theanine reduces norepinephrine and epinephrine activity/turnover and urinary excretion. EndoTrex can quickly reduce high neurotransmitter excretion making them more readily available for brain function.       EndoTrex is an easy to administer oral theanine spray and has a pleasant root beer flavor. EndoTrex is prepared without additional amino acids, vitamins, or minerals since these are generally not needed. Disclaimer
Other NeuroScience Products GobaMax PrevAmine Serene

Catecholamines are neural transmitters, and include dopamine, norepinephrine and epinephrine (adrenaline). Imbalance of catecholamines can result in autonomic dysfunction.

Theanine is a unique free form amino acid. It's a relaxant that increases alpha-waves producing mental and physical relaxation decreasing stress and anxiety, without inducing drowsiness. It is the therapeutic element in green tea, used in many products by the Japanese, however green tea also contains caffeine.

GABA, or gamma-amino butyric acid, is a messenger chemical that is essential for optimizing how brain cells transmit messages to each other and acts to put a damper on unwanted brain signaling activity

For more information on Endotrex and other Neuroscience Products,
go To NeuroScience Inc. http://www.neuroscienceinc.com

Research on Theanine Follows
General Research-Mood enhancement, Alpha waves and Mental focus
Theanine and ADHD-
                  Theanine has the potential to become a natural alternative to Ritalin for treating ADHD.
The Aging Mind Needs Theanine

In addition to relaxation, research suggests that L-theanine may have biological application in

1) diminishing symptoms of stress and anxiety in humans and pets,
2) improving ability to learn,
3) heightening mental acuity & neurotransmitter production,
4) promoting concentration and alpha brain waves,
5) Reducing the negative effects of caffeine and stimulants,
6) supporting the immune system,
7) lowering blood pressure,
8) increasing formation of the inhibitory neurotransmitter GABA
9) increasing brain dopamine levels among other positive benefits with no known downside,
10) reducing PMS symptoms

11)Optimizing neuron communication in the aging mind

Most of the research into is currently being conducted in the area of stress reduction without drowsiness, according to Mr. Smith. “Green tea is very unique in that it has very high levels of caffeine, even higher than coffee, depending on the variety. But it has also been noted that green tea is very calming,” explained Mr. Smith. “So we started to look at this contradictory situation and our research into L--theanine grew. L-theanine, in small amounts, is an antagonist to caffeine, so even though you are getting the positive effects of caffeine, in terms of staying alert, you are not getting the negative side effects associated with caffeine such as jitters and nausea.” Other areas of research include using L-theanine as an alternative to Ritalin, controlling blood pressure, sharpening mental acuity and concentration. 

Although green tea contains caffeine,  our L-theanine spray does not. Neuroscience has observed through testing EndoTrex that it reduces dopamine, norepinephrine, and epinephrine turnover and urinary excretion. It quickly reduces high levels of neurotransmitter excretion or "dumping". This allows the newly released neurotransmitters to be useful for concentration and brain function.

Documented Safety -

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L-Theanine: How a Unique Anxiety Reducer and Mood Enhancer Increases Alpha Waves and Alertness (Condensed)

by Carolyn Perrini, CLS, CNC

Hundreds of studies exist showing the many health benefits of green tea. But what makes it the most consumed beverage in the world after water is its pleasant taste and relaxation effect. Both of these qualities—and more—can be traced to a unique, neurologically-active amino acid in tea called L-theanine (gamma-ethylamino-L-glutamic acid).

L-theanine is a free (non-protein) amino acid found almost exclusively in tea plants ((Camellia sp.), constituting between 1 and 2-percent of the dry weight of tea leaves. Attempts to isolate the L-theanine, with its physical and neurological benefits, from the tea leaves were once difficult, expensive, and inefficient. Economically feasible methods of producing the identical L-theanine now exist and do not require a mountain of tea leaves.

Physiological Effects
The calming effect of green tea may seem contradictory to the stimulatory property of tea's caffeine content but it can be explained by the action of L-theanine. This amino acid actually acts antagonistically against the stimulatory effects of caffeine on the nervous system. (1) Research on human volunteers has demonstrated that L-theanine creates a sense of relaxation in approximately 30-40 minutes after ingestion via at least two different mechanisms. First, this amino acid directly stimulates the production of alpha brain waves, creating a state of deep relaxation and mental alertness similar to what is achieved through meditation. Second, L-theanine is involved in the formation of the inhibitory neurotransmitter, gamma amino butyric acid (GABA). GABA influences the levels of two other neurotransmitters, dopamine and serotonin, producing the key relaxation effect. (2)

Alpha Brain Activity
The brain emits weak electrical impulses (brain waves) that can be measured on the surface of the head. The predominant frequency of electrical impulses correlates with different types of mental states and activities. Brain waves are classified into four categories (delta, theta, alpha, and beta)—each with an associated mental state (Fig. 1). Delta is seen only in the deepest stages of sleep. Theta is seen in light sleep and drowsiness. Alpha is present in wakefulness where there is a relaxed and effortless alertness and Beta is seen in highly stressful situations and where there is difficulty in mental concentration and focus. It is well known that alpha brain waves are generated during a relaxed state and therefore alpha waves are used as an index of relaxation.

In one study of these mental responses to L-theanine, brain wave topography showed that alpha waves were observed from the back to the top of a person's head (occipital and parietal regions of the brain) within approximately 40 minutes after the subjects had taken either 50 or 200 mg of L-theanine. In a separate study, the intensity of alpha waves were determined to be dose dependent (with a 200 mg dose showing a significant increase over controls) and detectable after 30 minutes. (2,3)

Additional Benefits

The regulation of blood pressure is partly dependent upon catecholaminergic and serotonergic neurons in both the brain and the peripheral nervous system. Studies on spontaneously hypertensive rats (SHR) showed an impressive blood pressure lowering effect with L-theanine. The lowered blood pressure effect was dose-dependent with the highest test dose creating the most significant drop. L-glutamine was used as one of the controls. Although L-glutamine is similar in chemical structure to L-theanine, it did not exhibit an anti-hypertensive effect (Fig. 2). (3)

Preliminary studies report that L-theanine has been found to increase the anti-tumor activity of some chemotherapeutic agents (doxorubicin and idarubicin) and to ameliorate some of the side effects of these drugs. It appears to increase the inhibitory concentration of these drugs in the tumor cells, although the mechanism is not known. At the same time, L-theanine decreased oxidative stress caused by these agents on the normal cells, possibly due to its mild antioxidant activity. In this regard, L-theanine has been shown to inhibit lipid peroxidation, catalyzed by copper, in low-density lipoprotein (LDL) in vitro. (4))

Stress Relief
Stress and anxiety are debilitating conditions that upset the balance of our hormones leading to a loss of our well-being, performance, and even lifespan. Stress impairs the immune system, leaving us vulnerable to opportunistic infections, and can cause depression. In 1998, pharmaceutical sales of anti-anxiety drugs totaled over 700 million dollars, while sales of antidepressants totaled close to 5 billion dollars! L-theanine doesn't make one drowsy, nor does it promote sleep because this amino acid does not produce theta waves in the brain. It should be noted that if an individual were already relaxed, taking L-theanine would not produce further relaxation.